亿航生物

Custom Specifications

one thousand

particles

five hundred

particles

two hundred

particles

fifty

particles

five

particles

Promoting Tissue Repair and Regeneration

Bidirectional Immunomodulatory Effects

Signal Transduction and Metabolic Regulation

Antioxidant Stress Defense

Stem cell-derived exosomes are a class of tiny vesicles with diameters approximatelyranging from 30 to 150 nm, secreted by stem cells. Their formation process is relativelycomplex. Cells internalize extracellular substances through endocytosis to formendosomes, which gradually mature into late endosomes, also known as multivesicular bodies (MVBs). Finally, the MVBs fuse with the cell membrane, releasing exosomes intothe extracellular space. Exosomes are rich in various substances, including nucleic acids (such as miRNA, mRNA, and lncRNA), proteins (such as growth factors, cytokines, andenzymes), lipids (such as phospholipids, cholesterol, and sphingolipids), metabolites, andother small molecules (such as amino acids and vitamins).

INCI Registration

Introduction to INCI Names:

INCI stands for International Nomenclature of Cosmetic Ingredients, which is astandardized naming system for cosmetic ingredients. The INCI naming systemis established and administered by the International Nomenclature Committee, withtheaim of providing a unified, scientifically-based, and internationally-recognized namingmethod for various ingredients used in cosmetics.

Significance of INCI Registration for Stem Cell-Derived Exosome Ingredients:

For certain raw materials that lack a clear identity or standardized naming in the market, applying for an INCI name can offer an authoritative naming basis. This not onlyfacilitates the promotion and sale of these ingredients by enterprises in the international market but also simplifies the regulatory process for oversight agencies.

Comprehensive and Well-established Exosome Quality Control/Evaluation System

Classification	Quality Control Testing Items	Primary Testing Methods
Routine Inspection	Appearance	Visual Inspection Method
	Visible Foreign Particles	Light Inspection Method
Identification	Nanoparticle Size Distribution	MRPSINTAINanoFlow
	Exosome Morphology Quantitative & Qualitative Assays	TEM
	Marker Proteins (Three Positives, One Negative)	WB/NanoFlow
Purity	Particle Count per Protein	BCA#MRPSINTAINanoFlow
Concentration	Particle Count	MRPS\NTA\NanoFlow
Concentration	BCA Protein Quantification	BCA
Other physicochemical properties	pH	pH Meter
Other physicochemical properties	Osmolality	Freezing Point Method
Safety	Sterility Testing	Chinese Pharmacopoeia1101 Sterility Test Method
	Bacterial Endotoxin	Chinese Pharmacopoeia1143 Bacterial EndotoxinTest Method
	Mycoplasma	PCR Method
Impurities	Nuclease Residues	ELISA Method
Impurities	Host Cell DNA Residues Testing Methods	PCR Method

Classification	Evaluation Testing Items Skin-Related
Skin-Related	30+
Neurological-Related	10+
Pain-Related	6+
Parkinson's Prevention	6+
Sleep-Related	8+
...	...